Itraconazole is used to treat fungal nail infections. Itraconazole goes into your bloodstream and travels to the source of the infection underneath the nail so that it can fight the infection there.
The mechanism of action of itraconazole is the same as the other azole antifungals: it inhibits cytochrome P450 oxidase mediated synthesis of ergosterol.
Itraconazole is used for the treatment of fungal infections in both HIV- and non-HIV-infected individuals. It is active against fungal infections such as aspergillosis, blastomycosis, histoplasmosis, and candidiasis, as well as fungal infection localized to the toenails and fingernails (onychomycosis). It also is used for treating patients with fever and low white blood cell counts who are likely to develop a fungal infection.
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