Showing 13–24 of 41 results

Domperidone SR pellets

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Duloxetine HCL Pellets

Duloxetine HCL EC Pellets-Suitable for filling 20mg, 40mg & 60mg Capsules.

  • Release pattern compared with innovator
  • MKPPL objective is to develop duloxetine pellets by aqueous technology. Pellets developed by aqueous technology have advantage of avoiding the use of organic solvents.
  • All the ingredients are available for both FBC process and all the equipment’s including analytical instruments like HPLC, FTIR, GC and dissolution apparatus are available to develop duloxetine pellets.
  • Offer complete technical package for registrations in all regulated/semi regulated markets.
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Erlotinib MUPs / Granules

Erlotinib MUPs / Granules

  • The Development of premix of Erlotinib was done by Murli Krishna Pharma with the aim of overcoming:Poor bio-availability owing to poor solubility and reduction in toxicity through matrix based encapsulation.
  • The granules are ready for compression. The strength of the granules is 50% w/w. The granules can be employed for compression of tablets having the following strength: 50 mg/tablet (Tablet weight 100 mg) 100 mg/tablet (tablet weight 200 mg) and 150 mg/tablet (tablet weight 300 mg).
  • We offer development services in case of a requirement for different formulations/dosages/strengths
  • Offer complete technical package for registrations in all regulated/semi regulated markets
  • Products protected by ongoing Patents are not offered by MKPPL.
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Erlotinib Nano Particles

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Esomeprazole Pellets / Micro-Pellets / Premix

Esomeprazole Pellets / MUPs 8.5%, 22.5% – Suitable for Capsules, Tablets (dose: 20 mg, 40 mg)

  • Esomeprazole is the chiral form of omeprazole. The product is manufactured as enteric coated pellets by aqueous technology to match with Innovator without use of organic solvent.
  • The product developed is comparable with innovator with respect to dissolution profile of the marketed product.
  • The quality of the pellets is based on the in-vitro dissolution test besides the assay and the impurity profile. The time dissolution values are direct measures of the coating efficiency and hence optimum therapeutic efficacy as it has a co-relation with in-vivo behaviors.
  • We do offer development services in case of a requirement for different formulation/dosage/strength
  • Offer complete technical package for registrations in all regulated/semi regulated markets
  • Products protected by ongoing Patents are not offered by MKPPL.

Esomeprazole is also proton pump inhibitor and is one of the blockbuster molecule that is used in the treatment of ulcer.

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Everolimus Pellets

Everolimus Pellets – Available as Nanoparticles with 2.5%, 5% & 10% Strengths.

  • MKPPL is the first to come up with pellet based approach for immune suppressants.
  • Facilitates direct filling into capsules and can be easily employed in tableting. Nano particles can be effectively used for manufacturing of ointments (Tacrolimus) and solutions (Everolimus).
  • MKPPL pellet advantages includes using a micro emulsion technology. No cyclization of the drug, hence less delta lactones formation.
  • Coated pellets, hence the formulator does not require a contained facility for finished formulation.
  • Offer complete technical package for registrations in all regulated/semi regulated markets.
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Itraconazole Pellets

Itraconazole Pellets 22%, 40% – Suitable for Capsules (Dose: 100 mg, 200 mg)

Itraconazole belongs to the family of medications called antifungals. It is used to treat certain types of fungal infections, both internally (inside the body) and externally (skin and nails).

  • Itraconazole is used for the treatment of fungal infections in both HIV- and non-HIV-infected individuals.
  • The objective of developing Itraconazole pellets by aqueous technology is to match the dissolution profile of Itraconazole Pellets with SPORANOX without use of organic solvent.
  • The product developed is comparable with innovator with respect to dissolution profile of the marketed product.
  • We do offer development services in case of a requirement for different formulation/dosage/strength
  • Offer complete technical package for registrations in all regulated/semi regulated markets
  • Products protected by ongoing Patents are not offered by MKPPL.

 

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Lansoprazole Pellets / Micro Pellets / Premix

Lansoprazole Pellets-Suitable for filling in 15mg & 30mg Capsules, MUPS, Premix (sachet) & 30mg Tablets.

Lansoprazole is a second-generation proton pump inhibitor and is one of the blockbuster molecule that is used in the treatment of ulcers.

  • Release pattern compared with innovator -Prevacid delayed-release capsules and Prevacid solutab delayed-release orally disintegrating tablets.
  • A comparative dissolution was conducted for Lansoprazole capsules of Murli Krishna Pharma and prevacid capsules which compare favorably.
  • The focal intent of the MKPPL was to develop a stable; pharmaceutically equivalent, robust and delayed release micro pellet formulation of Lansoprazole for both capsule and orally disintegrating tablets.
  • Offer complete technical package for registrations in all regulated/semi regulated markets.
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Liposomal Iron, B12, Folic acid and Vitamin D3

Liposomal Iron, B12, Folic acid and Vitamin D3-Administered as Transdermal oil

  • Infant oil massage has been a traditional practice in India and MKPPL plans to leverage this practice to implement a technological innovation for delivery of micronutrients using fortified oils.
  • MKPPL have developed safe nano particles that encapsulate micronutrients and interact with the outermost layer of skin to enhance penetration and can be delivered through an oil platform.
  • Liposomal nano particle approach can be utilised for administering various vitamins through the dermal route and for delivering various antibiotics and anti –inflammatory agents through topical applications.
  • Offer complete technical package for registrations in all regulated/semi regulated markets.
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Mebeverine Pellets

Mebeverine Extended Release Pellets-Suitable for filling in 135mg & 200mg Capsules.

  • MKPPL achieved the desired sustained release profile equivalent to innovator
  • Mebeverine is an antispasmodic medicine which is taken to relieve bloating and cramp pain in the lower abdomen. These symptoms are commonly associated with the gastrointestinal condition called irritable bowel syndrome.
  • MKPPL aims to deliver Mebeverine as an inhibitor of calcium-depot replenishment. Musculotropic compounds act directly on the gut muscles at the cellular level to relax them. This relieves painful muscle spasms of the gut without affecting its normal motility.
  • Offer complete technical package for registrations in all regulated/semi regulated markets.
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Mesalamine Pellets / Granules / Premix

Mesalamine Pellets 70% – Suitable for Capsules (Dose: 500 mg)

Mesalamine is a drug used for treating ulcerative colitis. Although the exact mechanism of mesalamine is not known it is believed to be reducing the inflammation in the colon through systemic action.

  • Mesalamine is an anti-inflammatory agent used to treat ulcerative colitis. Mesalamine comes as a Delayed-release tablet, Delayed-release capsule, Controlled-release capsule, Extended-release capsule, Suppositories.
  • Mesalamine ER Pellets have dissolution time of 8 hours and are released as per the USP Monograph.
  • We do offer development services in case of a requirement for different formulation/dosage/strength
  • Offer complete technical package for registrations in all regulated/semi regulated markets
  • Products protected by ongoing Patents are not offered by MKPPL.

 

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Memantine HCL ER Pellets

Memantine HCL ER Pellets- Suitable for filling in Capsules- 14mg, 21mg & 28mg.

  • Release pattern compared with innovator Namenda XR.
  • MKPPL extended release pellets are the mixture of two types of pellets which are blended together to final strength of 10.56% w/w. this strength is dose equivalent and same pellets are used for different doses by changing the fill weight and capsule size for respective doses.
  • The formulation is based on the dispersion of drug in purified water and homogenization to reduce the particle size of active ingredient and to achieve the dissolution equivalent to innovator.
  • Offer complete technical package for registrations in all regulated/semi regulated markets.
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